ARPA-H ADVOCATE Program

Looking for a TA3 Clinical Partner

We built working TA1 and TA2 systems. UI Health (UIC) has already signed on as our first clinical site. Join us to submit a joint ADVOCATE proposal.

We bring

  • TA1 CVD Agent (Deutsch)

    In production, 4,000+ patients

  • TA2 Safety Supervisor (Popper)

    Deterministic 7-gate pipeline, 47ms

  • Hermes Protocol

    Open-source TA1-TA2 standard (Apache 2.0)

  • Pre-clinical evaluation

    68 vignettes, 6 scoring layers, 8 CVD conditions

You bring

  • HF / Post-MI patients

    Patient population for RCT enrollment

  • IRB infrastructure

    For multi-site clinical trial

  • EHR with FHIR R4 API

    Epic or similar, read-only integration

  • Clinical champion (PI)

    Site PI for the ADVOCATE trial

1 Site Confirmed

UI Health (University of Illinois Chicago)

LOI signed Feb 2026. Site PI: Dr. Mladen Vidovich, M.D., FACC, FSCAI. Epic EHR, IRB ready.

TA1 CVD Agent Built

DEUTSCH

Three-agent clinical reasoning via ArgMed debate. Protocol-bound GDMT optimization across CVD, nutrition, exercise, and mental health domains.

TA1↔TA2 Protocol Built

HERMES

Open-source communication standard (Apache 2.0) enabling any TA1 to work with any TA2. Structurally enforces epistemic metadata.

Open-source since Feb 5, 2026
TA2 Supervisory Built

POPPER

Deterministic safety supervision: 7-gate pipeline gating every clinical output in 47ms. No LLMs in the safety-critical path.

47ms median, <100ms target

What Sets Us Apart

Typical AI Proposals Regain Approach
Propose to build Demonstrate working software, 100% core complete
Black-box single-LLM reasoning Three-agent ArgMed debate with Hard-to-Vary scoring
ML model watching ML model Deterministic safety DSL. No LLMs in the safety-critical path
Single-vendor TA1↔TA2 coupling Open-source Hermes protocol: any TA1 works with any TA2

Ready to explore a TA3 partnership?

Ideal Participants: CMIO, CISO/IT Lead, Clinical Champion (PI)